What Causes High Sdma In Cats

August 20, 2021 Post a Comment

Your vet will likely want to run further tests to get to the root cause of the elevated SDMA values which could include a urine culture to test for an infection or an ultrasound of the kidney to check for kidney stones. It can be due to acute kidney injury AKI or chornic kidney disease CKD in dogs and cats.

Correlations Of Serum Creatinine Scr Sdma And Gfr In Dogs Affected Download Scientific Diagram

Both primary kidney disease.

What causes high sdma in cats. What Does SMDA Blood Test Reveal in Cats. How common is an increased SDMA result. An elevated SDMA concentration is a reflection of impaired glomerular filtration rate GFR.

Persistently elevated blood SDMA concentration 14 gdl may be used to diagnose early CKD. It is slightly higher in growing puppies than adult dogs. Conclusion and Clinical Importance.

There are three main species of methylated arginine. Symmetric dimethylarginine in hyperthyroid cats before and after treatment with radioactive iodine 2020 DeMonaco SM Panciera DL Morre WA Conway T Werre S Journal of Feline Medicine and Surgery 226 pp531-538 found that SDMA increases in cats treated with I131 for hyperthyroidism and states that SDMA should be considered alongside creatinine and USG in hyperthyroid cats before treatment. SDMA catches changes in how well the kidneys are filtering the blood much earlier than other tests mainly BUN and creatinine.

Serum SDMA concentration increases in the case of decreased kidney function. In some cases SDMA increases earlier. The SDMA value will start to increase when the kidneys have lost 40 of their filtering ability.

And secondary kidney insults such as concurrent disease can cause an elevation in SDMA concentration. Therefore as kidney function or GFR decreases SDMA increases. Sometimes resolving the elevated kidney values.

SDMA can catch changes when only 25 percent of kidney function is lost giving cats a better chance to respond to treatment. SDMA is a great tool to monitor yearly blood work in cats and can raise suspicion of reduced renal function before changes in kidney values levels are noted. 04 in a cat When SDMA result is 20 gdL YES History of weight loss decreased appetite polydipsia polyuria Physical examination findings.

The vet tried to explain to me the implications stressing that it could be an indication of the start of chronic kidney failure but it could also be a result of a kidney being damaged from birth in which case it would not necessarily get any worse. Serum SDMA had higher sensitivity 100 compared with sCr 17 but lower specicity 91 versus 100 and positive predictive value 86 versus 100. Without identifiable non-renal cause in cats not dogs abnormal renal palpation or renal imaging findings proteinuria of renal origin abnormal renal biopsy results increasing blood creatinine or SDMA concentrationsin samples collected serially.

Kidney disease is common with 1 in 3 cats 8 and 1 in 10 dogs 9 developing some form of kidney disease over their lifetimes. The horizontal line is the upper limit of the laboratorys reference interval for both SDMA 14 mcgdL and feline sCr 21 mgdL. Increased serum SDMA levels.

Prevalence increases with age. It is excreted from the bloodstream through the kidneys if the kidneys arent able to filter as well as they should like in chronic kidney disease or renal failure the SDMA will increase in the blood. An elevated SDMA is a more sensitive function indicator and elevations of SDMA in cats with normal creatinine values indicates reduced renal function known as stage 1 CKD.

Interpret your SDMA results. R2 of 085 in dogs. Available in late 2017 in-clinic on IDEXX Catalyst platform.

Shown a very strong correlation between SDMA and GFR R2 of 082 in cats. In addition SDMA is much less. Approximately 11 of dogs have an increased SDMA.

Approximately 26 of cats have an increased SDMA. The old tests BUN and creatinine dont show any changes until 70 to 80 percent of kidney function is lost. SDMA is made as the body processes protein.

SDMA increased above the reference interval approximately 8 months earlier than sCr. Symmetric Dimethylarginine SDMA Methylated arginines are byproducts of protein methylation released into blood during protein degradation. O Stable production of SDMA is part of daily cell activity o Excreted by the kidneys o A proven renal biomarker that that has been shown to correlate with glomerular filtration rate GFR in humans dogs and cats.

The benefit of using SDMA along with creatinine which typically increases above the reference interval only after a 75 reduction in GFR is that SDMA increases when there is on average a 40 decrease in GFR. Serum creatinine sCr and serum symmetric dimethylarginine SDMA concentrations over time in a cat that developed chronic kidney disease CKD. Studies have shown a very strong correlation between SDMA and GFR R 2.

Prevalence increases with age. Now available from IDEXX Reference Laboratories. Monomethylarginine MMA assymetric dimethylarginine ADMA and SDMA.

Using serum SDMA as a biomarker for CKD allows earlier detection of CKD in cats compared with sCr which may be desirable for initiating renoprotective interventions that slow. A few days later I was summoned to the vet and told that her SDMA was too high 122 molL reference value 075. SDMA is excreted from the kidneys.

On 4022012 when the SDMA.

Comparative Performance Of Idexx Sdma Test And The Dld Sdma Elisa For The Measurement Of Sdma In Canine And Feline Serum